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Best Electronic Lab Notebooks of 2021

overview of the electronic lab notebook market in 2021

The COVID-19 pandemic catalyzed a transition to a virtual workplace as access to physical facilities was restricted during most of 2020 and 2021. Just like video conferences have replaced in-person meetings,  laboratory notebooks have turned digital allowing laboratory personnel to do part of their jobs remotely. 

Choosing The Best Electronic Notebooks for your lab

We have all experienced the myriad of challenges with using old-fashioned paper lab notebooks. As labs have become increasingly digital, laboratory notebooks have become one component of a laboratory information management system that also includes nebulae of data files on desktop computers, shared drives, and cloud storage.

The paper notebook format is becoming increasingly inadequate in the digital laboratory. They’re tedious to write in, difficult to read, impossible to search, incapable of storing digital data, and easy to spill coffee on.

At some point, people may be tempted to replace the paper notebooks with various Word documents or Wiki pages; but none of these approaches meet the requirements of electronic laboratory notebooks. In order to facilitate your successful adoption of a cloud-based solution to data management, we reviewed the ELN solutions on the market in 2021. Here, we review the top six electronic lab notebook (ELN) solutions.

ELN vendors promise a number of benefits associated with the use of their products:

  1. Enhanced productivity and efficiency
  2. Increased organization
  3. Greater collaboration 
  4. Fewer sources of error or ambiguity 
  5. More repeatable, reproducible research

After deciding to transition from physical paper to digital documentation in your lab, one encounters a new issue: option overload. It is particularly challenging to test an ELN solution.

The value of these products as well as their limitations only become apparent after they have been used for some time. Selecting the wrong tool can derail research instead of enhancing it. Therefore, selecting the correct ELN solution is a critical decision. 

Unfortunately, this decision isn’t quick or simple. A plethora of ELNs exists with various specialties and organizational strategies. The size and structure of your team along with the complexity of the projects you contribute to may guide you in one direction or another.  

Integrations with specific apps like DNA sequence visualization or drawing chemical molecular structures may also influence your choice. The regulatory environment in which you operate is another factor to consider.  

In order to achieve the best results possible, it’s worth taking the time to do some comparison shopping before adopting an ELN. To assist in your decision, we have thoughtfully reviewed the marketplace and identified the top six ELN software solutions along with 3 runner-ups. 


GenoFAB launched in April 2021. Unlike other software vendors that provide separate Laboratory Information Management Systems and Electronic Laboratory Notebooks solutions, GenoFAB integrates the two functions into a single application. 

It provides a powerful templating system that dramatically accelerates ELN record-keeping. Users can standardize reporting requirements for different kinds of experiments. Notebook entries are automatically linked to the Standard Operating Procedures or Protocol describing the laboratory operations. This approach allows scientists eliminates the duplication of content that is a common limitation of many ELN products. It allows scientists to focus on articulating the hypothesis tested by an experiment, reporting the data, and interpreting the experiment results. 

GenoFAB allows users to attach a broad range of data files to their notebook entries without size restrictions. Some attachments like pdf files and images can be viewed directly in the browser. 

GenoFAB does not charge a subscription per user. It does have no annual contracts. Instead, it charges users a flat fee per notebook entry. This model makes it possible for potential users to evaluate the product in realistic conditions without taking a significant financial risk. 

Every GenoFAB account comes with no restriction on the amount of data storage, the number of users, or access to the most advanced features. 


eLabJournal is a software product developed by Bio-ITech, a dutch software company. It offers a comprehensive electronic lab notebook that can be expanded to a laboratory information management system. Eppendorf acquired Bio-ITech in 2017.

The eLabJournal entry-level solutions are two public-cloud plans for academic, and industry users. Their monthly prices are $15.55 per user for academics and $41.95 per user for academics. Both prices are for teams of 50 members.  Private cloud hosting and on-premise installations are also available. 

They boast compatibility with Microsoft Excel, making it easy to upload and analyze data from your experiments. You can even sync and add files to the experiment section of your ELN with your mobile device. They also provide 20GB of storage with each plan per user and offer expanded plans for larger groups. Daily back-ups, experiment timelines, and sample tracking are all available as well.    

They have extensive multi-user sharing features available, so sharing with collaborators across the world is a breeze. PIs and project managers have easy access to seeing the progress made by their team, which is also made available on a mobile device. 

Despite offering extensive sharing and oversight features, they do not compromise on security features. They offer electronic signatures, counter-signatures, two-step identification verification, and various other features that seek to preserve the confidentiality of your study.

Every change within their ELN is followed by a full audit trail, leading to extremely efficient accountability. Their compliance features, general stability, and respectability seem to set them apart from others that offer similar products: making them a solid choice for your organization. 


BIOVIA is a software company based in the USA but has a presence in Europe and Asia. BIOVIA acquired Contur Software AB in 2011 and rebranded its ELN product. This ELN is part of a much larger offering of applications supporting the life cycles research and development projects. 

Since it is not possible to access their blog posts without creating an account, it can be challenging to get product information from the website. However,  they regularly provide product demonstrations in very informative webinars. 

They recommend their services to organizations of all sizes. They offer a hybrid cloud approach, hosted with Amazon Web Services. Like many others available, their online ELN syncs with an on-premise integration. The ELN fits in seamlessly with its online workflow management system tools.

This product is compatible with Windows and Mac. Its interface is depicted intuitively for all using hierarchical flow charts to show the workflow stages during your experiment, follow-up communication, and data analysis. They also offer cool visualization features (BIOVIA Draw, MarvinSketch, ChemDraw, and ISIS Draw). So drawing and storing images of your synthetic chemical structures is a breeze. 

In terms of regulatory compliance, the product provides timed digital signatures and counter-signatures as a part of its workflow experience. It is also 21 CFR section 11 compliant, making them a great option to automate your processes and accelerate your workflow while exceeding FDA compliance regulations.

No price information is publicly available. 


SciNote is an open-source ELN originally developed by a team in Slovenia. The company is now headquartered in Wisconsin and is a joint venture between BioSistemika LLC and Gilson Inc

They offer academic and corporate plans allowing users to choose between a private cloud or on-premise deployment options. A free plan allows a single user to manage unlimited items in one inventory per user and 1 GB of free storage. They have three other pricing tiers geared towards single teams or slews of teams within a major organization.

SciNote has a project-centric approach to record-keeping. It helps users to describe their projects using a hierarchy – from the project all the way to individual tasks. 

In some ways, SciNote can be regarded as a workflow management system. It keeps track of the tasks completed by different people and generates reports on demand. The platform also includes an intriguing add-on to assist in writing manuscripts by automating the process of pulling data from the system. 

Most notably, SciNote also enables audit trails and electronic signatures as a part of its 21 CFR Part 11 add-on within the Industry license. SciNote is also GDPR, GLP & GMP Compliant and provides immediate data encryption during collection. 

Their suite of audit trails and regulatory compliance makes them another attractive option to customers. 

No price information is publicly available. 


Founded in Israel in 2011, LabGuru has been a major player in the electronic lab notebook industry for some time. They offer a secure, cloud-based ELN with more than the normal suite of ELN tools. 

LabGuru hosts a suite of the typical services offered from ELNs, but has optimized their inventory tracking and budget assistance tools, making them indispensable to CROs. With their budget and inventory tools, they lean closer to a hybrid ELN/LIMS system than a baseline ELN. 

Specifically, they have implemented smart coding and barcoding, which syncs with your ELN and lab inventory easily. As a result, you’re able to search for data and reagents quickly as needed. 

They also have a strong application programming interface, making it easy to connect and analyze data from various other software applications. 

Like the other leading ELNs on the market, LabGuru has been optimized for global collaboration and regulatory compliance. Users can access your profile from any device without issue. They offer advanced editor features for drawing and storing chemical structures, editing text, tables, or sketches. 

No price information is publicly available. 


Benchling is the most recent ELN product. This San Francisco-based startup has produced a sleek and stylish product. Founded in 2012, it has received more than $300 M in funding so far. 

In a market where a lot of players seem to have received limited attention, Benchling has become a rock star in academia. It is widely praised by innumerable academic institutions, especially for its molecular biology geared tools. The fact that Benchling offers a free hosting plan for Academics probably helps. 

Benchling's success doesn't end in academia though. Many biotechnology companies also utilize the upgraded versions to great success. Reviewers cite the ease of collaboration, compliance, sleek design, and inventory management as the main features that incite such a following.

There is an abundance of features available that most people love, but some reviewers have said that the options can feel slightly redundant.

Overall, Benchling consists of a suite of software solutions, including a lab notebook, but the tight integrations between the different modules make it more than an ELN. A very distinctive feature of Benchling is the abundance of bioinformatics tools that are embedded in the system. Specifically, they have CRISPR design guides, primer design guides, and sequence alignment tools deeply integrated with their ELN product.

Other ELNs to consider

RSpace, LabFolders, and LabArchives are document management solutions positioned as Electronic Laboratory Notebooks. They may be suited to large deployments involving groups working in different disciplines.

Take Action

Need help deciding if you should adopt an Electronic Laboratory Notebook for your organization? Schedule an introductory demo to tell us about your lab. This will help us prepare a custom demonstration showing how GenoFAB can increase the productivity of your team. 




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